Series creator and director Goichi Suda had received many fan requests to make a third mainline entry in the franchise after the release of the second game, but development of a new entry was postponed for many years due to Grasshopper Manufacture working on other projects. Production began during the final development stages of the spinoff prequel Travis Strikes Again: No More Heroes (2019).
Set eleven years after the events of No More Heroes 2: Desperate Struggle (2010), the game stars professional assassin Travis Touchdown and follows his return to the fictional city of Santa Destroy, as he must defend the world from a powerful army of alien invaders led by the galactic overlord prince FU and his nine soldiers who adopt the façade of galactic superheroes.
It is the fourth installment in the No More Heroes series and is the third mainline entry in the series. No More Heroes III is a 2021 action-adventure video game developed and published by Grasshopper Manufacture for the Nintendo Switch.